PTH Summary

Dr. Jody Rusch’s simplistic explanation of PTH and its measurement

n-truncated are deficient in the first few aa’s (7-84) – hence biologically inactive.

1-11 aa sequence is necessary for function.

Different assays:

  • Intact PTH measurements: 7-84 and 1-84
  • Bioactive PTH: 1-84
  • CAP assay: cAMP inducible PTH. This assay determines the biologically active PTH by its ability to induce cAMP.
  • PTHrP assays and PTH assays are exclusive to each other by design.